Ole Gunnar Solskjaer has confirmed Anthony Martial and Jesse Lingard are out for three weeks with injury
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Lingard suffered a hamstring injury in the first leg of their last-16 Champions League tie against Paris Saint-Germain at Old Trafford. The winger was ruled out of the game during the first-half stoppage.
Meanwhile Martial was also injured earlier in the game and played until the interval but did not reappear for the second half.
Solskjaer has confirmed on his pre- FA Cup match conference that the duo will remain sidelined until mid-march, meaning they will miss Manchester United's games against Chelsea and Liverpool.
"I think they will be out for two to three weeks looking at it now," said the Manchester United care taker.
"It is a chance for anyone who plays, whether it is Alexis, Romelu or Angel (Gomes).
"Anthony and Jesse have done really well for us, they are vital in the attacking parts with their pace.
"Romelu and Alexis have different skill sets, so we just need to gel a team together for Monday now."
Young duo Angel Gomes and Tahith Chong have been training with United's first team in recent weeks and Solskjaer says the pair now have a "big chance" of being involved against Chelsea and Liverpool.
"It might be (time for Gomes or Chong to come in)," he added.
"We still have forward options but Angel and Chongy have been training with us all week, even the weeks leading up to this, so there is a big chance they will be involved."