Jurgen Klopp has confirmed Fabinho will be unavailable for the Reds' trip to Leicester on Saturday
Fabinho who returned for the Reds in the 4-1 home defeat to City last weekend will now sit out the contest at King Power Stadium due to muscle issues.
Jurgen Klopp confirmed the player's muscle injury could further stretch into the games against RB Leipzig and Everton.
The Liverpool boss confirmed on his pre-match conference.
But, asked whether deadline day signings Ozan Kabak or Ben Davies could debut at centre-back, Klopp admitted he was wary of the threat posed by Leicester's "world-class" striker Jamie Vardy.
Klopp said: "Jamie is obviously a proper challenge in this league. We can only do that with the whole team, you have to avoid the passes to him. He's a world-class player for sure, in a specific area of the pitch and with his speed that's really tricky.
"With the boys, we've had some sessions together where we could work on this defensive setup, and that's very important, but we have as well other players available. Nate Phillips did really well together with Hendo [Jordan Henderson] and Fab.
"Fab will not be available by the way, he suffered again a little muscle issue so will be out for this game. So we have to find a solution, all of them had the chance this week to show in training who's ready, so I have to make a decision tomorrow.
"I don't know [if he will miss Leipzig/Everton] in the moment, we will see. I really don't know."